A teenage prodigy, Moise Kean, netted twice as Juventus secured a 3-1 victory over Udinese, extending their Serie A lead to 19 points.
Cristiano Ronaldo remained on the bench as Juventus focused on their upcoming Champions League clash against Atletico Madrid, which they lost 2-0 in the first leg.
Kean opened the scoring by converting Alex Sandro's cross and added a second after a solo run into the box. He also earned a penalty, which Emre Can converted, before Blaise Matuidi headed in a third goal. Udinese's Kevin Lasagna scored a consolation goal.
This marked Kean's seventh Serie A goal of the season, following his lone league start for Juventus in 2017. The 19-year-old, who earned one cap for Italy, spent last season on loan at Verona.
This was the first time this season that Ronaldo was not selected for a Juventus match.
Since relocating to the Allianz Stadium in 2011, Juventus has claimed seven consecutive Serie A titles. They currently lead Napoli by 19 points, with the latter set to face Sassuolo on Sunday.
Udinese introduced England Under-20 midfielder Ben Wilmot, a January loan acquisition from Watford, though he was substituted at halftime.
In other developments, Claudio Ranieri was appointed as Roma's interim manager until the season's end. The 67-year-old, previously dismissed by Fulham after three wins in 17 games, returns to Roma, where he previously managed from 2009 to 2011.
Ranieri expressed his excitement, stating, "When Roma calls, it's impossible to refuse." He replaces Eusebio di Francesco, who was sacked after a 4-3 aggregate loss to Porto in the Champions League last 16.